Rapid Diagnosis - Enigma FL - foot and mouth etc
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http://enigmadiagnostics.com/ufiles/30JUN09%20VLA%20BVDV%20Trial.pdf

Extract

"...The system itself is broadly applicable to many other veterinary pathogens, such as TB in cattle, bacterial infections and other viral infections, such as foot and mouth disease and avian influenza. Allowing vets to use advanced molecular diagnosis in the field will enhance their efficiency in managing endemic and exotic disease outbreaks identifying diseased animals and as importantly, non-infected ones, and improve their surveillance capability"

PRESS RELEASE

 30 June 2009

ENIGMA DIAGNOSTICS ANNOUNCES SUCCESSFUL EVALUATION OF THE

ENIGMA FL BY THE UK’s VETERINARY LABORATORIES AGENCY

Porton Down, UK

 

 – Enigma Diagnostics Limited, the decentralised and point-of-care

molecular diagnostics company, announced today successful independent testing for

bovine viral diarrhoea (BVD) by the Veterinary Laboratories Agency to evaluate the

performance of the Enigma FL (Field Laboratory).

BVD is considered to be one of the main threats to cattle [1], affecting the majority of

herds in the UK. It is closely related to classical swine fever virus, a serious disease of

pigs, and to border disease virus, which infects sheep.

The Enigma FL instrument was used to analyse more than 100 blood samples that had

already been screened by antigen ELISA and a laboratory-based RT-PCR for the

presence of the BVD virus. Approximately half of the samples were proved BVDV

positive by the laboratory-based PCR. With the level of concordance between the two

tests being above 97%, this confirmed the Enigma FL system can produce laboratorystandard

results with a high degree of confidence.

The Enigma FL has been designed for easy operation. Tests are provided in a singleuse

cartridge that can be stored at room temperature. The Enigma FL provides a PCR

result in less than one hour, a timescale needed to allow field-based & pen-side

diagnosis. On-site testing removes delays from transport of samples to the laboratory,

which can often take days. The system requires minimal training and its utility for “penside”

testing for BVD has already been demonstrated [2].

John McKinley, Chairman and CEO of Enigma, stated: “The Enigma Diagnostics tests

could be deployed for the related viral diseases, such as classical swine fever, with

minor modifications. The system itself is broadly applicable to many other veterinary

pathogens, such as TB in cattle, bacterial infections and other viral infections, such as

foot and mouth disease and avian influenza. Allowing vets to use advanced molecular

diagnosis in the field will enhance their efficiency in managing endemic and exotic

disease outbreaks identifying diseased animals and as importantly, non-infected ones

and improve their surveillance capability”.

 

(1) http://www.rvc.ac.uk/BVD/documents/BVD_Disease.ppt

(2) http://enigmadiagnostics.com/template2.php?page=news.php&m=4

Fully automated instrumentation for nucleic acid testing in the field.

Squirrell, D.J., Lee, M.A. and Wakeley, P. Water Contamination Emergencies:

Collective Responsibility, J.Gray & K.C.Thompson eds., Royal Society of Chemistry

Special Publication No.317, RSC Publishing, Cambridge, UK, p.238-244, 2009.